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Candidate Gene Association Studies
 Bhismadev Chakrabarti, Frank Dudbridge, Sharmila Banerjee Basu, L. Kent, Simon Baron-Cohen, Sally Wheelwright, Jon Breidbord, Uma Mallya, Grant Hill-Cawthorne, Lindsay Chura
This genetic association study is examining specific candidate genes chosen for their role in neural development or neural function, to see if single nucleotide polymorphisms (SNPs) in these candidate genes differ in their frequencey between cases and controls; or if these SNPs are associated with phenotypic measures that we have developed (such as the Autism Spectrum Quotient (AQ)). We are also conducting full genome association scans using chips with 50,000 SNPs. We aim to test if the same or different associations are found in Asperger Syndrome and classic autism.
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References:
390
F. Chinnery, S. Wheelwright, S. Baron-Cohen, C. Lambert, A. Pyle, H. Elliott and L. Kent, (2006)
The Mitochondrial DNA A3243A>G Mutation Must Be An Infrequent Cause Of Asperger Syndrome
Journal of Pediatrics :281.e1
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317
B. Chakrabarti, L. Kent, J. Suckling, E. Bullmore and S. Baron-Cohen, (2006)
Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
European Journal of Neuroscience 23(7):1944-8
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101
S. Baron-Cohen and J. Hammer, (1997)
Parents of children with Asperger Syndrome: what is the cognitive phenotype?
Journal of Cognitive Neuroscience 9:548-554
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